I Am Worried That My Childhood Friend Is Too Cute!Ore no Tomodachi ♂♀ ga Kawaisugite Komaru!; 俺の友達♂♀が可愛すぎて困る！; My Childhood Friend Is So Cute, It's Frustrating!; I Am Worried That My Childhood Friend Is Too Cute!; Người bạn thời thơ ấu của tôi quá dễ thương!; Мой друг детства слишком милый!; My Childhood Friend Was Turn Into Girl Because a Disease

Amano, who returned to the city where he lived as a child for the first time in 10 years, meet Yukio Sawatari, a childhood friend on the first day of transfer, when he (a male friend) turned female! Although she shares her joy, as she suddenly turns into a girl and cannot hide her embarrassment. Yukio was affected by an illness like 100,000 other people, suddenly becoming a girl so-called " spontaneous isomerism metamorphosis ''! The female childhood friend ♂ is cute and in trouble!? Forbidden TSF (transsexual) Love!